The MOTIVATE Study

Metabolic Optimization and Training InterVentions for Aging and Type 2 Diabetes to Enhance cognition: the MOTIVATE Study

map-marker.pngThames Hall, Robarts Research Institute, Elborn College, and Public Health and Family Medicine Building on Western University Campus

Type 2 diabetes (T2D) can negatively affect thinking and memory. Keeping blood sugar well controlled, along with positive lifestyle changes such as exercise, plays an important role in protecting brain health. This study is looking at ways to help older adults with T2D improve both their brain health through blood sugar control and exercise. Participants will take a medication called semaglutide or receive standard diabetes care, combined with a structured exercise program over 32 weeks. The study will measure how these approaches affect memory, thinking, and daily functioning, as well as physical fitness and blood sugar levels. The goal is to find safe and effective strategies to support healthier brains, bodies, and lifestyles in older adults living with type 2 diabetes.

Adults 65+ years old

Type 2 Diabetes

Not currently exercising more than once per week

Who can participate in this study?

  • Individuals 65-years-old or older
  • Have Type 2 Diabetes
  • Have not participated regularly in exercise forthe last 6 months
  • Have not been diagnosed with neurodegenerative or musculoskeletal disorders
  • Have not had a stroke or heart attack

What is involved?

Our study involves 4 visits to start the study that include questionnaires, health assessments, and cognitive and physical function testing. Some visits will include a blood draw, an MRI scan to capture an image of your brain and DXA scan to measure body fat and bone density. Each visit will take 1-2 hours. Then, participants will follow a structured exercise program 3 times per week for 1 hour and, depending on their group, take either semaglutide or continue with standard diabetes care for the first 16 weeks. Participants will also be asked to track their medication use, exercise, and any health changes. The first 3 visits will be repeated at the halfway point and end of the study.

Principal Investigator & Posting Dates

Principal Investigator: Lindsay Nagamatsu
Study posted on: September 9th, 2026
Recruitment open

Who can I contact to learn more about this study?

For more information please contact: 

Olivia Ghosh-Swaby: oghoshsw@uwo.ca

 

 

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