Distinguishing the roles of ventral and dorsal striatum in cognition

Distinguishing the roles of ventral and dorsal striatum in cognition

map-marker.pngWestern Interdisciplinary Research Building (WIRB) & Robarts Research Institute (RRI)

Have you ever wondered how the brain allows us to move, think, make choices, and experience reward? Our lab investigates the striatum, a brain region involved in these complex processes. We also want to find out how it is that damage to the striatum causes diseases like Parkinson’s disease, substance use disorder, and obsessive compulsive disorder.

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Both male and female

18 years old to 80 years old

Please view full study for details


Who can participate in this study?

Individuals between the ages of 18 and 80 (priority given to healthy elderly adults) who meet the following criteria:

Healthy Volunteers:
-       No history of neurological or major psychiatric disorder
-       No previous experience of epileptic seizures
-       No history of substance abuse (e.g., alcohol or prescription drugs)
-       Not currently taking medications that are contraindicated for dopamine administration (e.g., Aricept (Donepezil), Reminyl (Galantamine), Exelon (Rivastigmine), or Memantine (Ebixa))
-       No contraindications for MRI scanning (e.g., no metal or eletronic implants, no claustrophobia)

Individuals who have been diagnosed with alcohol addiction:
-       No contraindications for MRI scanning (e.g., no metal or eletronic implants, no claustrophobia)

Individuals who have been diagnosed with obsessive compulsive disorder (OCD):
-       No contraindications for MRI scanning (e.g., no metal or eletronic implants, no claustrophobia)

What is involved?

Participants are asked to complete two study sessions where they will perform a range of cognitive and behavioral tasks and fill out questionnaires. Some studies involve scenarios in virtual reality or a driving simulator, while other studies involve MRI/fMRI scanning. Our studies typically last approximately three hours per session.

Principal Investigator & Posting Dates

Principal Investigator: Penny MacDonald
Study posted on: November 22nd, 2018
Recruitment open until: November 29th, 2023

Who can I contact to learn more about this study?

For more information please contact: 

The Penny MacDonald Lab
519-663-3631
519-661-2111 ext. 80271
pmacdonaldlab@gmail.com

 

 

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